Aldehyde Dehydrogenase 2 Protects Against Post-Cardiac Arrest Myocardial Dysfunction Through a Novel Mechanism of Suppressing Mitochondrial Reactive Oxygen Species Production

Post-cardiac arrest myocardial dysfunction significantly contributes to early mortality after the return of spontaneous circulation.However, no effective therapy is available now.Aldehyde dehydrogenase 2 (ALDH2) enzyme has been shown to protect the heart from aldehyde toxicity such as 4-hydroxy-2-nonenal (4-HNE) and oxidative stress.In this DETANGL

read more


An information theoretic method to resolve millisecond-scale spike timing precision in a comprehensive motor program.

Sensory inputs in nervous systems are often encoded at the millisecond scale in a precise spike timing code.There is now growing evidence in behaviors ranging from slow breathing to rapid flight for the prevalence of precise timing encoding in motor systems.Despite this, we largely do not know at what scale timing matters in these circuits due to t

read more